A Four-Antigen Mixture for Rapid Assessment of Onchocerca volvulus Infection
نویسندگان
چکیده
منابع مشابه
A Four-Antigen Mixture for Rapid Assessment of Onchocerca volvulus Infection
BACKGROUND Onchocerciasis, an infection caused by the filarial nematode Onchocerca volvulus, is a major public health concern. Given the debilitating symptoms associated with onchocerciasis and concerns about recrudescence in areas of previous onchocerciasis control, more efficient tools are needed for diagnosis and monitoring of control measures. We investigated whether luciferase immunoprecip...
متن کاملDevelopment of a recombinant antigen vaccine against infection with the filarial worm Onchocerca volvulus.
Efforts to control Onchocerca volvulus, the etiologic agent of river blindness, have been limited to vector control and drug treatment to eliminate microfilariae, with no means available to prevent infection. The goal of this study was to develop a vaccine against this infection using recombinant antigens that are expressed in the early larval stages of the parasite. Five recombinant antigens, ...
متن کاملMolecular cloning of an immunodominant antigen of Onchocerca volvulus
We have cloned and characterized the gene for an immunodominant antigen of O. volvulus that is recognized by the sera of 96% of patients with onchocerciasis. Its 1.2-kb mRNA constitutes 0.3% of adult worm poly(A)+ RNA and its cDNA sequence reveals that it is not a highly conserved structural protein such as actin or tubulin. Similar but not identical genes occur in the genomes of related filari...
متن کاملRapid Point-of-Contact Tool for Mapping and Integrated Surveillance of Wuchereria bancrofti and Onchocerca volvulus Infection.
Elimination programs for Wuchereria bancrofti and Onchocerca volvulus are in critical need of sensitive, specific, and point-of-contact (POC) tools that can be used for surveillance years beyond cessation of mass drug administration when infection intensities are low. Previously, Wb123 and Ov16 were identified individually as potential filarial antigens for an antibody-based POC test. The prese...
متن کاملCharacterization of an immunodominant Onchocerca volvulus antigen with patient sera and a monoclonal antibody
Adult Onchocerca voluvlus and infective larvae, but not microfilariae contain an immunodominant antigen (33,000 and 21,000 Mr in females, 39,000, 33,000, and 21,000 Mr in males, 133,000 Mr in infective larvae) which is recognized by an Onchocerca-specific mAb. The component is part of the reproductive organs and muscles. 96.2% of onchocerciasis sera contained antibodies detectable by immunoblot...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2009
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0000438